THESIS ON SCRUB TYPHUS

THESIS ON SCRUB TYPHUS

Scrub typhus in Darjeeling, India: The blood samples were collected from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. Jpn J Infect Dis. Nested PCR for detection of 56 kDa gene specific for Orientia tsutsugamushi with good sensitivity of and specificity may be recommended in laboratories with molecular lab facility [ 14 ]. The current gold standard for serology is Indirect Immunofluorescence Antibody IFA test which uses a fluorescence labelled anti-human immunoglobulin to detect antibodies in patients serum that have bound to immobilised bacterial antigen that is coated on the IFA slide. Clinical diagnosis of scrub typhus is challenging as the signs and symptoms of scrub typhus are similar to other febrile illnesses. Open in a separate window.

Articles from Journal of Clinical and Diagnostic Research: Introduction Scrub typhus has been one of the most covert emerging and re-emerging Rickettsial infections with increasing trend in incidences of the disease worldwide including India. An estimated one billion people are at risk for scrub typhus and one million cases occur annually [ 12 ]. Indian J Med Res. Therefore it is recommended to perform both pathogen and antibody based tests. The disease is usually underdiagnosed in India due to the non-specific clinical manifestations, lack of access to specific and sensitive diagnostic tests in most places and low index of suspicion among the clinicians. Find articles by K.

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Published online Nov 1. The patients attending this hospital as both inpatients and outpatients who were clinically diagnosed to theeis typhus fever were included. This is hospital based study which has its own limitations, therefore future research can be carried out with community-based study to get more data on seroprevalance of scrub typhus in Pondicherry.

Nested PCR for detection of 56 kDa gene specific for Orientia tsutsugamushi with good sensitivity of and specificity may be recommended in laboratories with molecular lab facility [ 14 ]. The culturing of the organism is not only inappropriate as the time duration of the same is not effective enough for the early diagnosis of scrub typhus. National Center for Biotechnology InformationU.

  SGU THESIS GARUDA

thesis on scrub typhus

Molecular diagnosis of scrub typhus: IFA being the gold standard for serology of scrub typhus is considered as imperfect with its own limitations [ 15 ]. Abstract Introduction Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections.

thesis on scrub typhus

Specimen collection and processing The blood samples were thewis from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. Conclusion The medical fraternity needs typus understand the pitfalls of currently available Weil-Felix test which is still common in India and must include tests with better performance like IgM ELISA and nested PCR in the diagnostic algorithm of scrub typhus to reduce the burden of the disease.

Indian J Med Microbiol. The clinical symptoms are fever, headache, myalgia, malaise, rash and lymphadenopathy which are commonly seen in other acute febrile illness like malaria, enteric fever, leptospirosis, dengue etc. The blood samples were collected from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. Materials and Methods It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

Am J Trop Med Hyg. Acknowledgement for financial support and specific contribution only: An emerging infectious threat. Expert Rev Anti Infect Ther. The medical fraternity needs to understand the pitfalls of currently available Weil-Felix test which is still common in Tgesis and must include tests with better performance like IgM ELISA and nested PCR in the diagnostic algorithm of scrub typhus to reduce the burden of the disease.

  JK ROWLING HARVARD COMMENCEMENT SPEECH THESIS

thesis on scrub typhus

The infection is thrsis by bite of larval stage chiggers of mites belonging to the family Trombiculidae. The disease treatment can be easily affordable with anti-rickettsial drugs, if accurate and precise diagnosis is made which can help in the speedy recovery of the patients.

J Clin Diagn Res. The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix test and IFA test in diagnosis of scrub typhus. Scrub typhus in Darjeeling, India: Scrub typhus is widespread, extending from Japan to Australia and from India to Pacific [ 2 thwsis. A prospective study on distribution of eschar in patients suspected of scrub typhus. The vast variability and common clinical manifestations of the disease which is similar to other febrile illnesses makes the clinical diagnosis challenging.

There is an upsurge in the incidence of the disease worldwide with ever-changing habitat.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

The test was standardised with serum samples from healthy blood donors. Jpn J Infect Dis. Support Center Support Center.

A study was conducted in Delhi among the febrile paediatric patients which did not have definitive diagnosis. The severity of illness vary from mild to severe with multiorgan system involvement and cause deaths if not treated accurately at the early stage of illness, otherwise the treatment is affordable and mostly successful with dramatic clinical response to anti-rickettsial drugs within 48 hours.

First case of scrub typhus with meningoencephalitis from Kerala: