THESIS ON SCRUB TYPHUS

THESIS ON SCRUB TYPHUS

The test is widely in use as it is cheap, easily available and does not require technical expertise. The blood samples were collected from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. The patients age varied from 10 months to 80 years were taken for the study. The Immunofluorescence antibody IFA test has its limitations in terms of cost and expertise required. Find articles by K. Serological evidence of rickettsial infections in Delhi. The severity of illness vary from mild to severe with multiorgan system involvement and cause deaths if not treated accurately at the early stage of illness, otherwise the treatment is affordable and mostly successful with dramatic clinical response to anti-rickettsial drugs within 48 hours.

It is a prospective study which was carried out between January to June 3 years 6 months , in a tertiary care hospital in Puducherry, South India. The severity of illness vary from mild to severe with multiorgan system involvement and cause deaths if not treated accurately at the early stage of illness, otherwise the treatment is affordable and mostly successful with dramatic clinical response to anti-rickettsial drugs within 48 hours. Nested PCR for detection of 56 kDa gene specific for Orientia tsutsugamushi with good sensitivity of and specificity may be recommended in laboratories with molecular lab facility [ 14 ]. The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix test and IFA test in diagnosis of scrub typhus. Investigation of an outbreak of scrub typhus in the himalayan region of India. A study carried out by Kamarasu et al. The mite acts as both vector and reservoir of the bacteria and efficiently transmits to its off springs through transovarian transmission.

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J Assoc Physicians India. A study was conducted in Delhi among the febrile paediatric patients which did not have definitive diagnosis.

thesis on scrub typhus

None Acknowledgement for financial support and specific contribution only: Jpn J Infect Dis. Investigation of an outbreak of scrub typhus in the himalayan region of India.

Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections. A prospective study on distribution of eschar in patients suspected of scrub typhus.

The most widely performed laboratory test in India is Weil-Felix test which has low sensitivity and specificity. The current gold standard is imperfect as it is expensive requiring a fluorescence microscope.

Therefore the disease has been urbanised and the prevalence of the disease has broadened further [ 1 ]. The drawback of serology test is that the advantage of testing directly the presence of organism is not possible [ 14 ]. The most common diagnostic test in India is the Weil-Felix test.

thesis on scrub typhus

J Clin Diagn Res. Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. Find articles by K. The infection is transmitted by bite of larval stage chiggers of mites belonging to the family Trombiculidae.

The mite acts as both vector and reservoir of the bacteria and efficiently transmits to its off springs through transovarian transmission. Materials thesiss Methods It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India.

The disease is usually underdiagnosed in India due to the non-specific thseis manifestations, lack of access to specific and sensitive diagnostic tests in most places and low index of suspicion among the clinicians.

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Therefore it is recommended to perform both pathogen and antibody based tests. Thesos Indian Acad Neurol. Comparative evaluation of selected diagnostic assays for the detection of IgG and IgM antibody to Orientia tsutsugamushi in Thailand.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

typhuz An emerging infectious threat. Diagnosis of scrub thesjs. Articles from Journal of Clinical and Diagnostic Research: Recently, in India there are scrub typhus reports from Goa where the disease was not documented earlier indicating the occurrence of the disease in previously unidentified regions [ 3 ].

The patients who had a history of fever with or without eschar and rash and also had more than 2 symptoms such as head ache, myalgia, malaise, nausea, abdominal discomfort were included.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

Scrub typhus is widespread, extending from Japan to Australia and from India to Pacific [ 2 ]. In our study single time point estimation is done, which is a major drawback.

This again emphasises the fact that Weil-Felix test is typhu a sensitive test for diagnosis of scrub typhus. Author information Article notes Copyright and License information Disclaimer. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. Though the presence of eschar typhis helpful in making a diagnostic clue for scrub typhus it is not always present.

Am J Trop Med Hyg. Scrub typhus being the re-emerging zoonosis is increasingly recognised in India.