THESIS ON SCRUB TYPHUS

THESIS ON SCRUB TYPHUS

With either delay in diagnosis or administration of inappropriate antimicrobial therapy can lead to severe complications such as Acute Respiratory Distress Syndrome ARDS , septic shock and multisystem organ failure often causing death in patients. IFA being the gold standard for serology of scrub typhus is considered as imperfect with its own limitations [ 15 ]. This is hospital based study which has its own limitations, therefore future research can be carried out with community-based study to get more data on seroprevalance of scrub typhus in Pondicherry. Though the presence of eschar is helpful in making a diagnostic clue for scrub typhus it is not always present. The disease is usually underdiagnosed in India due to the non-specific clinical manifestations, lack of access to specific and sensitive diagnostic tests in most places and low index of suspicion among the clinicians. Scrub typhus in Darjeeling, India: Find articles by Chanaveerappa Bammigatti.

In developing countries, among the various laboratory tests to diagnose scrub typhus, Weil-Felix test is commonly performed despite its low sensitivity. IFA being the gold standard for serology of scrub typhus is considered as imperfect with its own limitations [ 15 ]. The organism is also extremely dangerous requiring BSL—III facility for its culture which is impractical in most laboratories in India [ 15 ]. Is scrub typhus a cause of febrile illness among paediatric population of delhi? Asian J Pharm Clin Res. All serological tests are retrospective where diagnosis is done at the end of one week. National Center for Biotechnology Information , U.

The patients age varied from 10 months to 80 years were taken for the study.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

Ann Indian Acad Neurol. The culturing of the organism is not only inappropriate typbus the time duration of the same is not effective enough for the early diagnosis of scrub typhus. Find articles by K. Published online Nov 1. The severity of illness vary from mild to severe with multiorgan system involvement and cause deaths if not treated accurately at the early stage of illness, otherwise the treatment is affordable and mostly successful with dramatic clinical response to anti-rickettsial drugs within 48 hours.

  ELKMONT ALABAMA GOAT FARM ESSAY

A set of positive and negative controls were included along with every test reaction. J Assoc Physicians India.

thesis on scrub typhus

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The disease is usually underdiagnosed in India due to the non-specific clinical manifestations, lack of access to specific and sensitive diagnostic tests in most places and low index of suspicion among the clinicians. Though it is rationally considered as disease found in rural areas, it is also well described from urban areas like Delhi and Chennai infecting people, as the tiny mite islands are seen in the vegetation around the dwellings.

Possibility of scrub typhus in fever of unknown origin Ttphus cases: Scrub typhus in Darjeeling, India: Discussion Scrub typhus being the re-emerging zoonosis is increasingly recognised in India.

Diagnosis of scrub typhus. The study was conducted only after obtaining written informed consent from the patients. Molecular tests like nested PCR for diagnosis acts as a viable, early and accurate diagnostic tool as compared with that of serological tests.

It also requires considerable training for both performing the test and interpretation of the result. Find articles by Chanaveerappa Bammigatti. The test is widely in use as it is cheap, easily available and does not require technical expertise.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

The patients who had a history of fever with or without eschar and rash and also had more than 2 symptoms such as head scrrub, myalgia, malaise, nausea, abdominal discomfort were included. Abstract Introduction Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections. Typhus fever in Pondicherry. Indian J Med Microbiol.

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thesis on scrub typhus

After screening patients with acute febrile illness with a battery of diagnostic tests such as Para F for malaria, Widal tests, ICT for dengue and Ig M ELISA for leptospirosis, 63 samples reacted positively for above mentioned tests and were excluded. It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India.

The infection is transmitted by bite of larval stage chiggers of mites belonging to the family Trombiculidae. Expert Rev Anti Infect Ther. Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order.

Investigation of an outbreak of scrub typhus in the himalayan region of India. Specimen collection and processing The blood samples were collected from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. Recently, in India there are scrub typhus reports from Goa where the disease was not documented earlier indicating the occurrence of the disease in previously unidentified regions [ 3 ].

thesis on scrub typhus

Am J Trop Med Hyg. A study was conducted in Delhi among the febrile paediatric patients which did not have definitive diagnosis. The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix typhuz and IFA test in diagnosis of scrub typhus.

The disease is also transmitted from larval stage of mites to rats, where man is an accidental host.