The remaining 33 articles qualified as Level IV evidence, showing substantial, consistent, and rapid pain relief [ 91 — 95 ] a few representative references are cited here; for a comprehensive list, please refer to the review by McGirt et al. To establish the relative strengths and weaknesses of all these procedures, well-designed randomized clinical trials are required. Previously, the only surgical option to treat VCF involving decompression and fusion often failed in elderly patients due to osteopenia [ 1 ]. Comparison of injectable calcium phosphate cement and polymethylmethacrylate for use in vertebroplasty: Murphy KJ, Deramond H. Acknowledgments The authors acknowledge the assistance of www. Prospective evaluation of pain relief in patients undergoing percutaneous vertebroplasty:

The component monomer MMA of the most commonly used bone cement, PMMA, was known for its toxicity on cells as well as neurotoxicity, and hence a chemical effect was postulated for the pain relief [ 59 , 60 ]. Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: Extravasation of bone cement into epidural spaces leads to more serious complications. Once injected, its main function is the transfer of forces from bone-to-implant and implant-to-bone. Clinical outcome PV and KP are the most routinely used minimally invasive procedures to treat osteoporotic or tumor-associated VCFs with the primary aim of relieving pain. With the help of osteotomes, site-specific cavities are created inside the fractured vertebra. Fribourg D, et al.

vertebroplasty bone cement thesis

Both procedures have been proven to be superior to oral pain management. Adjacent vertebral fractures after percutaneous vertebral augmentation of osteoporotic vertebral compression fracture: Extravasation cemnet bone cement into epidural spaces leads to more serious complications. In kyphoplasty, a bone tamp is inserted to create a cavity before injecting the bone cement, while this Nitinol implant-based method involves the placement of the implant inside the vertebral body after making the pathway for the implant by using a coaxial manual drill.


The pain is mainly related to the motion of the end plate and the micromotion of the trabecular fractures — both these conditions are the most common histologic findings in osteoporotic fractures[ 7071 ]. A histologic study of fractured human vertebral bodies.

Few new generation bioactive bone cements have been found to induce new bone formation and also have good mechanical stability. Clinical studies consistent with these findings found little difference in vertebral height gain between PV and PK.

They are sold under different brand names bkne slightly in composition: Among these 35, there was no study that qualified for Level I ranking, and a single Level II study was published in 2 separate manuscripts [ 8990 ].

Intravertebral clefts in osteoporotic vertebral compression fractures. After the uni- or bipedicular access is obtained, the bone cement is injected.

To establish the relative strengths and weaknesses of all these procedures, well-designed randomized clinical trials are required. Different approaches have been used for the advancement of the cannula followed by the injection of the bone cement.

Vertebral cancellous bone can also be a source of pain.

Current status of percutaneous vertebroplasty and percutaneous kyphoplasty – a review

Comparative analysis between shape memory alloy-based correction and traditional correction technique in pedicle screws constructs for treating severe scoliosis. The biomechanical effects of kyphoplasty on treated and adjacent non treated vertebral bodies. Evaluation of consecutives procedures. Degenerative lumbar spinal stenosis: This literature review presents a qualitative overview on the current status of vertebral augmentation procedures, especially PV and PK, and compares the efficacy and safety of these 2 procedures.

Current status of percutaneous vertebroplasty and percutaneous kyphoplasty – a review

Balloon kyphoplasty of vertebral compression fractures with a new calcium phosphate cement. Therefore, debate still exists regarding the superiority of one procedure over the other.


vertebroplasty bone cement thesis

Pecutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral compression fractures: Support Center Thezis Center. Material properties of various cements for use with vertebroplasty. This provided immediate pain relief after curing of bone cement, suggesting the restoration of mechanical stability in a clinical outcome study [ 72 ].

vertebroplasty bone cement thesis

The first human in vivo study for measuring the polymerization temperature of different bone cements was performed by Anselmetti et al. For this purpose a radiopaque agent such as tantalum powder, tungsten, barium sulfate, or zirconium dioxide is incorporated into the solid phase.

There also remain several other relative contraindications. Temperature elevation veftebroplasty by bone cement polymerization during vertebroplasty. Risk of new vertebral fracture in the year following a fracture.

Leakage of monomer was also reduced after the curing phase [ 33 ]. Published online Oct 7. Temperature elevation after vertebroplasty with polymethyl-methacrylate in the goat spine. However, calcium phosphate-based bone cements are still in the development stage in vitro and there are few animal studies [ 37 — 40 ]. The first percutaneous vertebroplasty was performed in by Gakibert and Deramond, interventional neuroradiologists in Amiens, France.

An ex vivo biomechanical evaluation verttebroplasty a hydroxyapatite cement for use with Kyphoplasty.